Structure of PDB 1shh Chain B

Receptor sequence

>1shhB (length=252) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWKG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QF

3D structure

• PDB: 1shh Molecular dissection of na+ binding to thrombin.
• Chain: B
• Resolution: 1.55 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D102 E192 G193 D194 S195 G196
• Catalytic site (residue number reindexed from 1): H43 D99 E197 G198 D199 S200 G201
• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	E23 G25 M26 P28 W29 H119 P120 C122 Y134 K135 R137 N159 K202 N205 R206 W207 Y208	E8 G10 M11 P13 W14 H116 P117 C119 Y134 K135 R137 N159 K207 N212 R213 W214 Y215
BS02	0G6	B	H57 Y60A L99 I174 D189 A190 S195 S214 W215 G216	H43 Y47 L96 I174 D194 A195 S200 S221 W222 G223

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1shh, PDBe:1shh, PDBj:1shh
• PDBsum: 1shh
• PubMed: 15152000
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)