Structure of PDB 1sg4 Chain B

Receptor sequence
>1sg4B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
QRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGV
ILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVS
AINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLE
NTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWM
AIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYL
ERLKEEKG
3D structure
PDB1sg4 The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.
ChainB
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L66 M71 W83 Q87 G111 L114 N135 E136 P144 D229
Catalytic site (residue number reindexed from 1) L64 M69 W81 Q85 G109 L112 N133 E134 P142 D227
Enzyme Commision number 5.3.3.8: Delta(3)-Delta(2)-enoyl-CoA isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO8 B P24 V25 V61 A64 L66 D67 L68 P109 A110 G111 L139 I142 L255 K256 K259 P22 V23 V59 A62 L64 D65 L66 P107 A108 G109 L137 I140 L253 K254 K257
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:1sg4, PDBe:1sg4, PDBj:1sg4
PDBsum1sg4
PubMed15351645
UniProtP42126|ECI1_HUMAN Enoyl-CoA delta isomerase 1, mitochondrial (Gene Name=ECI1)

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