Structure of PDB 1sb3 Chain B

Receptor sequence

>1sb3B (length=323) Species: 59405 (Thauera aromatica)

MNILTDFRTHRPATLADAVNALAAEATLPLGAGTDLLPNLRRGLGHPAAL
VDLTGIDGLATISTLADGSLRIGAGATLEAIAEHDAIRTTWPALAQAAES
VAGPTHRAAATLGGNLCQDTRCTFYNQSEWWRSGNGYCLKYKGDKCHVIV
KSDRCYATYHGDVAPALMVLDARAEIVGPAGKRTVPVAQLFRESGAEHLT
LEKGELLAAIEVPPTGAWSAAYSKVRIRDAVDFPLAGVAAALQRDGDRIA
GLRVAITGSNSAPLMVPVDALLGGNWDDAAAETLAQLVRKTSNVLRTTIT
GVKYRRRVLLAISRKVVDQLWEA

3D structure

• PDB: 1sb3 Structure of a Xanthine Oxidase-Related 4-Hydroxybenzoyl-CoA Reductase with an Additional [4Fe-4S] Cluster and an Inverted Electron Flow.
• Chain: B
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 1.1.7.1: 4-hydroxybenzoyl-CoA reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	P29 G31 A32 G33 T34 D35 L36 L53 V101 A102 A110 T111 G114 N115 C117 Q118 D162 L207 V231 D232 F233	P29 G31 A32 G33 T34 D35 L36 L53 V101 A102 A110 T111 G114 N115 C117 Q118 D162 L207 V231 D232 F233
BS02	SF4	B	C122 C138 K140 C146 H147 C155 Y156 A157	C122 C138 K140 C146 H147 C155 Y156 A157

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0018525 4-hydroxybenzoyl-CoA reductase activity
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051539 4 iron, 4 sulfur cluster binding
• GO:0071949 FAD binding

External links

• PDB: RCSB:1sb3, PDBe:1sb3, PDBj:1sb3
• PDBsum: 1sb3
• PubMed: 15576037
• UniProt: O33820|HCRB_THAAR 4-hydroxybenzoyl-CoA reductase subunit beta (Gene Name=hcrB)