Structure of PDB 1s9i Chain B

Receptor sequence
>1s9iB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
TQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIK
PAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV
LKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI
KLCDFGVSGQLIDSMTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGR
YPIPPPDAKELEAIFGRMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNK
CLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRL
3D structure
PDB1s9i Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D194 K196 S198 N199 D212 D221 T230
Catalytic site (residue number reindexed from 1) D136 K138 S140 N141 D154 D163 T166
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N199 D212 N141 D154
BS02 ATP B L78 G79 G81 N82 V86 A99 K101 M147 M150 S154 Q157 K196 L201 L20 G21 G23 N24 V28 A41 K43 M89 M92 S96 Q99 K138 L143
BS03 5EA B K101 L122 V131 D212 F213 G214 V215 S216 L219 M223 K43 L64 V73 D154 F155 G156 V157 S158 L161 M165
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s9i, PDBe:1s9i, PDBj:1s9i
PDBsum1s9i
PubMed15543157
UniProtP36507|MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (Gene Name=MAP2K2)

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