Structure of PDB 1s4d Chain B

Receptor sequence
>1s4dB (length=263) Species: 43306 (Pseudomonas denitrificans (nom. rej.)) [Search protein sequence]
DLFAGLPALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNED
CLKLARPGAVLEFAGKRGGKPSPKQRDISLRLVELARAGNRVLRLKGGDP
FVFGRGGEEALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVT
FLTGHDSSGVPDRINWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPD
EPVAFVCNAATPQQAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAA
LDWIGALDGRKLA
3D structure
PDB1s4d Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D47 K69 M184
Catalytic site (residue number reindexed from 1) D44 K66 M180
Enzyme Commision number 2.1.1.107: uroporphyrinogen-III C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B P24 L49 G100 G101 D102 V105 T130 A131 Y183 M184 N212 A213 P240 A241 I242 P21 L46 G97 G98 D99 V102 T127 A128 Y179 M180 N208 A209 P236 A237 I238 PDBbind-CN: -logKd/Ki=6.49,Ki=0.32uM
Gene Ontology
Molecular Function
GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s4d, PDBe:1s4d, PDBj:1s4d
PDBsum1s4d
PubMed15522295
UniProtP21631|SUMT_SINSX Uroporphyrinogen-III C-methyltransferase (Gene Name=cobA)

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