Structure of PDB 1s17 Chain B

Receptor sequence
>1s17B (length=164) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AILNILEFPDPRLRTIAKPVEVVDDAVRQLIDDMFETMYEAPGIGLAATQ
VNVHKRIVVMDLSEDKSEPRVFINPEFEPLTEEMDQYQEGCLSVPGFYEN
VDRPQKVRIKALDRDGNPFEEVAEGLLAVCIQHECDHLNGKLFVDYLSTL
KRDRIRKKLEKQHR
3D structure
PDB1s17 Identification of novel potent bicyclic peptide deformylase inhibitors
ChainB
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G46 Q51 C92 L93 H134 E135 H138
Catalytic site (residue number reindexed from 1) G45 Q50 C91 L92 H133 E134 H137
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNR B I45 G46 Q51 Y88 E90 G91 C92 L93 H134 E135 H138 I44 G45 Q50 Y87 E89 G90 C91 L92 H133 E134 H137 MOAD: ic50<5nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

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Molecular Function
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Biological Process
External links
PDB RCSB:1s17, PDBe:1s17, PDBj:1s17
PDBsum1s17
PubMed15006385
UniProtQ9I7A8|DEF_PSEAE Peptide deformylase (Gene Name=def)

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