Structure of PDB 1rwx Chain B

Receptor sequence
>1rwxB (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV
EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
3D structure
PDB1rwx Tethering identifies fragment that yields potent inhibitors of human caspase-1.
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E74
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YBH B S339 R341 H342 R352 D381 R383 S23 R25 H26 R36 D65 R67 PDBbind-CN: -logKd/Ki=7.37,Ki=43nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1rwx, PDBe:1rwx, PDBj:1rwx
PDBsum1rwx
PubMed16274992
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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