Structure of PDB 1rwn Chain B

Receptor sequence
>1rwnB (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV
EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
3D structure
PDB1rwn Structural analysis of caspase-1 inhibitors derived from Tethering.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E74
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4QB B V338 S339 W340 R341 H342 M345 G346 R383 V22 S23 W24 R25 H26 M29 G30 R67
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1rwn, PDBe:1rwn, PDBj:1rwn
PDBsum1rwn
PubMed16511067
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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