Structure of PDB 1rtf Chain B

Receptor sequence
>1rtfB (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
IKGGLFADIASHPWQAAIFAKHGERFLCGGILISSCWILSAAHCFQERFP
PHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKS
DSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLK
EAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRNLHDACQGDSGGPLVCL
NDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
3D structure
PDB1rtf The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D92 Q190 G191 D192 S193 G194
Enzyme Commision number 3.4.21.68: t-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I16 A25 S26 R119 T120 V121 C122 E137 R206 M207 I1 A10 S11 R113 T114 V115 C116 E131 R204 M205
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1rtf, PDBe:1rtf, PDBj:1rtf
PDBsum1rtf
PubMed8613982
UniProtP00750|TPA_HUMAN Tissue-type plasminogen activator (Gene Name=PLAT)

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