Structure of PDB 1rsg Chain B

Receptor sequence
>1rsgB (length=491) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGR
KYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRV
DHDKELLLEIVDNEMSKFAELEFHQHLCSFFQLVMKYLLQRRQFLTNDQI
RYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQS
FPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLS
VQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESS
KIVTLANSTNEFVEIVRNAENLDELDSMLERETSVTCWSQPLFFVNLSKS
TGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVID
GMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPVDMVVAMSNGQ
DSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKLEH
3D structure
PDB1rsg Crystal structures of fms1 and its complex with spermine reveal substrate specificity.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H67
Catalytic site (residue number reindexed from 1) H60
Enzyme Commision number 1.5.3.17: non-specific polyamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G15 G17 I18 A19 E39 A40 R41 G46 R47 G62 A63 S64 W65 H67 V223 V253 G270 L294 G478 E479 C488 A489 A492 G8 G10 I11 A12 E32 A33 R34 G39 R40 G55 A56 S57 W58 H60 V212 V242 G259 L283 G458 E459 C468 A469 A472
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901 spermine oxidase activity
GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006338 chromatin remodeling
GO:0015940 pantothenate biosynthetic process
GO:0046208 spermine catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rsg, PDBe:1rsg, PDBj:1rsg
PDBsum1rsg
PubMed15843025
UniProtP50264|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

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