Structure of PDB 1rrv Chain B

Receptor sequence

>1rrvB (length=400) Species: 31958 (Amycolatopsis orientalis)

MRVLLSVCGTRGDVEIGVALADRLKALGVQTRMCAPPAAEERLAEVGVPH
VPVGLPQHMMLQEGMPPPPPEEEQRLAAMTVEMQFDAVPGAAEGCAAVVA
VGDLAAATGVRSVAEKLGLPFFYSVPSPVYLASPHLPPAYDEPTTPGVTD
IRVLWEERAARFADRYGPTLNRRRAEIGLPPVEDVFGYGHGERPLLAADP
VLAPLQPDVDAVQTGAWLLSDERPLPPELEAFLAAGSPPVHIGFGSSSGR
GIADAAKVAVEAIRAQGRRVILSRGWTELVLPDDRDDCFAIDEVNFQALF
RRVAAVIHHGSAGTEHVATRAGVPQLVIPRNTDQPYFAGRVAALGIGVAH
DGPTPTFESLSAALTTVLAPETRARAEAVAGMVLTDGAAAAADLVLAAVG

3D structure

• PDB: 1rrv Crystal Structure of Vancosaminyltransferase Gtfd from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands
• Chain: B
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.322: devancosaminyl-vancomycin vancosaminetransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	C8 G9 T10 M60 L61 Q62 M65 P67 L76 T80 D141 P143 Y166 N331	C8 G9 T10 M60 L61 Q62 M65 P67 L76 T80 D141 P143 Y166 N331
BS02	TYD	B	T10 R11 G12 E15 S246 E293 V294 F296 H309 S311 G313 T314	T10 R11 G12 E15 S246 E293 V294 F296 H309 S311 G313 T314
BS03	BGC	B	D13 G102 D103	D13 G102 D103

Gene Ontology

Molecular Function

• GO:0008194 UDP-glycosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0016758 hexosyltransferase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0017000 antibiotic biosynthetic process
• GO:0030259 lipid glycosylation
• GO:0033072 vancomycin biosynthetic process

External links

• PDB: RCSB:1rrv, PDBe:1rrv, PDBj:1rrv
• PDBsum: 1rrv
• PubMed: 15122882
• UniProt: Q9AFC7|GTFD_AMYOR Devancosaminyl-vancomycin vancosaminetransferase (Gene Name=gtfD)