Structure of PDB 1rqj Chain B

Receptor sequence
>1rqjB (length=298) Species: 562 (Escherichia coli) [Search protein sequence]
DFPQQLEACVKQANQALSRFIAPLPFQNTPVVETMQYGALLGGKRLRPFL
VYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLPTC
HVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASASGI
AGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGDKG
RRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYP
ALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK
3D structure
PDB1rqj Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D105 D111 D83 D89
BS02 MG B D105 D111 D83 D89
BS03 IPE B G65 K66 R69 H98 R117 F240 D244 G43 K44 R47 H76 R95 F218 D222
BS04 RIS B D105 R116 Q179 K202 T203 D244 K258 D83 R94 Q157 K180 T181 D222 K236
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:1rqj, PDBe:1rqj, PDBj:1rqj
PDBsum1rqj
PubMed14672944
UniProtP22939|ISPA_ECOLI Farnesyl diphosphate synthase (Gene Name=ispA)

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