Structure of PDB 1rqi Chain B

Receptor sequence
>1rqiB (length=298) Species: 562 (Escherichia coli) [Search protein sequence]
DFPQQLEACVKQANQALSRFIAPLPFQNTPVVETMQYGALLGGKRLRPFL
VYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLPTC
HVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASASGI
AGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGDKG
RRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYP
ALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK
3D structure
PDB1rqi Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
ChainB
Resolution2.42 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D105 D111 D83 D89
BS02 MG B D105 D111 D83 D89
BS03 DST B S101 D105 R116 M175 Q179 K202 D244 K258 S79 D83 R94 M153 Q157 K180 D222 K236
BS04 IPR B G65 K66 R69 H98 L102 R117 F240 D244 G43 K44 R47 H76 L80 R95 F218 D222
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1rqi, PDBe:1rqi, PDBj:1rqi
PDBsum1rqi
PubMed14672944
UniProtP22939|ISPA_ECOLI Farnesyl diphosphate synthase (Gene Name=ispA)

[Back to BioLiP]