Structure of PDB 1rqf Chain B

Receptor sequence

>1rqfB (length=165) Species: 8355 (Xenopus laevis)

EVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILD
LEPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVY
CENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGF
PHMLFMVHPEYRPKR

3D structure

• PDB: 1rqf Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop.
• Chain: B
• Resolution: 2.89 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.37: Transferred entry: 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	A85 R86 D126 G160	A72 R73 D113 G147
BS02	peptide	B	Y113 N116	Y100 N103
BS03	ZN	B	C109 C114 C137 C140	C96 C101 C124 C127

Gene Ontology

Molecular Function

• GO:0019887 protein kinase regulator activity

Cellular Component

• GO:0005956 protein kinase CK2 complex

External links

• PDB: RCSB:1rqf, PDBe:1rqf, PDBj:1rqf
• PDBsum: 1rqf
• PubMed: 15388915
• UniProt: P28021|CSK2B_XENLA Casein kinase II subunit beta (Gene Name=csnk2b)