Structure of PDB 1rl8 Chain B

Receptor sequence

>1rl8B (length=99) Species: 11676 (Human immunodeficiency virus 1)

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGAWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF

3D structure

• PDB: 1rl8 Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
• Chain: B
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D25 T26 G27
• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RIT	B	D25 G27 A28 D29 G48 G49 I50 I84	D25 G27 A28 D29 G48 G49 I50 I84

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1rl8, PDBe:1rl8, PDBj:1rl8
• PDBsum: 1rl8
• UniProt: P03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)