Structure of PDB 1rg2 Chain B

Receptor sequence
>1rg2B (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]
DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDV
DWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIA
FGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADG
THKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGST
PGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADE
SKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA
EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANL
SKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPY
DLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
3D structure
PDB1rg2 Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y204 F259 H263 S400 G402 P461 S518 A520 W590 Y46 F101 H105 S242 G244 P294 S351 A353 W416
BS02 VO4 B H263 K265 H493 K495 H105 K107 H326 K328 BindingDB: IC50=4000nM
BS03 OTS B Y204 G458 S459 H493 W590 Y46 G291 S292 H326 W416
BS04 OTR B Y204 G458 S459 H493 Y46 G291 S292 H326
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:1rg2, PDBe:1rg2, PDBj:1rg2
PDBsum1rg2
PubMed14761185
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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