Structure of PDB 1rf6 Chain B

Receptor sequence
>1rf6B (length=427) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MKLKTNIRHLHGIIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLS
TMQVFRDLGVEIEDKDGVITVQGVGMAGLKAPQNALNMGNSGTSIRLISG
VLAGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLK
GTKNLRPIHYELPIASAQVKSALMFAALQAKGESVIIEKEYTRNHTEDML
QQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWLVAGLIAPNSR
LVLQNVGINETRTGIIDVIRAMGGKLEITEIDPVAKSATLIVESSDLKGT
EICGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADA
LNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADG
EVELDRAEAINTSYPSFFDDLESLIHG
3D structure
PDB1rf6 Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K20 S21 D47 N90 D115 R120 D312 E340 H384 R385 T412
Catalytic site (residue number reindexed from 1) K20 S21 D47 N90 D115 R120 D312 E340 H384 R385 T412
Enzyme Commision number 2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GPJ B K20 G92 T93 R120 Q168 D312 E340 R343 H384 R385 K20 G92 T93 R120 Q168 D312 E340 R343 H384 R385
BS02 S3P B S21 R25 S166 Q168 R193 D312 K339 S21 R25 S166 Q168 R193 D312 K339
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1rf6, PDBe:1rf6, PDBj:1rf6
PDBsum1rf6
PubMed14763973
UniProtQ9S400|AROA_STRPN 3-phosphoshikimate 1-carboxyvinyltransferase (Gene Name=aroA)

[Back to BioLiP]