Structure of PDB 1r4f Chain B

Receptor sequence
>1r4fB (length=314) Species: 5699 (Trypanosoma vivax) [Search protein sequence]
SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVT
GKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPE
NVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKY
GEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGC
PGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMYAADAL
TAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEA
EFFLDMLLRSARAC
3D structure
PDB1r4f Leaving group activation by aromatic stacking: an alternative to general Acid catalysis.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D10 D15 D40 W83 T137 W185 N186 A260 D261
Catalytic site (residue number reindexed from 1) D10 D15 D40 W83 T137 W185 N186 A247 D248
Enzyme Commision number 3.2.2.1: purine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D10 D15 T137 D261 D10 D15 T137 D248
BS02 AD3 B N12 D14 D40 W83 M164 N173 E184 N186 D261 N12 D14 D40 W83 M164 N173 E184 N186 D248
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1r4f, PDBe:1r4f, PDBj:1r4f
PDBsum1r4f
PubMed15050818
UniProtQ9GPQ4

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