Structure of PDB 1r0x Chain B

Receptor sequence
>1r0xB (length=265) Species: 10090 (Mus musculus) [Search protein sequence]
TTGIIMENVTAFWEEGFGELLEKSFSHLCLVGNPVLKNINLNIEKGEMLA
ITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKEN
IIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRAR
ISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTS
KMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTE
ERRSSILTETLRRFS
3D structure
PDB1r0x Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T465 Q493 T60 Q88
BS02 ATP B W401 F430 T460 G461 G463 K464 T465 S466 Q493 W13 F25 T55 G56 G58 K59 T60 S61 Q88 MOAD: Kd=149uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1r0x, PDBe:1r0x, PDBj:1r0x
PDBsum1r0x
PubMed14685259
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

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