Structure of PDB 1qiw Chain B

Receptor sequence

>1qiwB (length=143) Species: 9913 (Bos taurus)

LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIN
EVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAA
ELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

3D structure

• PDB: 1qiw A New Potent Calmodulin Antagonist with Arylalkylamine Structure: Crystallographic, Spectroscopic and Functional Studies
• Chain: B
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): V35
• Catalytic site (residue number reindexed from 1): V32

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	D20 D22 D24 T26 E31	D17 D19 D21 T23 E28
BS02	CA	B	D56 D58 N60 T62 E67	D53 D55 N57 T59 E64
BS03	CA	B	D93 D95 N97 Y99 E104	D90 D92 N94 Y96 E101
BS04	CA	B	D129 D131 D133 Q135 E140	D126 D128 D130 Q132 E137
BS05	DPD	B	E11 F12 M76 F92 L105 M109 M124 M144 M145	E8 F9 M73 F89 L102 M106 M121 M141 M142	MOAD: Kd=18nM

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0046872 metal ion binding

Biological Process

• GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
• GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

• GO:0000922 spindle pole
• GO:0005737 cytoplasm
• GO:0005819 spindle
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1qiw, PDBe:1qiw, PDBj:1qiw
• PDBsum: 1qiw
• PubMed: 10731425
• UniProt: P62157|CALM_BOVIN Calmodulin (Gene Name=CALM)