Structure of PDB 1qcw Chain B

Receptor sequence
>1qcwB (length=385) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGANDE
VTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATALCK
LGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWY
QLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQKEKDMKLKFSKFI
DPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVLSNHGGR
QLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKALCLGA
KGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAELKPD
LLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
3D structure
PDB1qcw Kinetic and crystallographic studies on the active site Arg289Lys mutant of flavocytochrome b2 (yeast L-lactate dehydrogenase)
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S228 Y254 T280 D282 K349 H373
Catalytic site (residue number reindexed from 1) S127 Y153 T179 D181 K223 H247
Enzyme Commision number 1.1.2.3: L-lactate dehydrogenase (cytochrome).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FNS B Y143 Y144 S195 A196 T197 A198 S228 Q252 Y254 T280 K349 H373 R376 D409 G410 R413 G432 R433 Y42 Y43 S94 A95 T96 A97 S127 Q151 Y153 T179 K223 H247 R250 D283 G284 R287 G306 R307
Gene Ontology
Molecular Function
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1qcw, PDBe:1qcw, PDBj:1qcw
PDBsum1qcw
PubMed10727218
UniProtP00175|CYB2_YEAST L-lactate dehydrogenase (cytochrome) (Gene Name=CYB2)

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