Structure of PDB 1q5m Chain B

Receptor sequence
>1q5mB (length=322) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
DPKFQRVALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDS
AYFYKNEKEVGLAIRSKIADGTVKREDIFYTSKLWCTFHRPELVRPSLED
SLKNLQLDYVDLYIIHFPTALKPGVEIIPTDEHGKAIFDTVDICATWEAM
EKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQGK
LLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAKKHQQT
PALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNR
NFRYVTADFAIGHPNYPFSDEY
3D structure
PDB1q5m Loop Relaxation, A Mechanism that Explains the Reduced Specificity of Rabbit 20alpha-Hydroxysteroid Dehydrogenase, A Member of the Aldo-Keto Reductase Superfamily.
ChainB
Resolution1.32 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D50 Y55 K84 H117
Catalytic site (residue number reindexed from 1) D49 Y54 K83 H116
Enzyme Commision number 1.1.1.149: 20alpha-hydroxysteroid dehydrogenase.
1.1.1.189: prostaglandin-E2 9-reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B G22 T23 Y24 D50 Y55 H117 Q190 Y216 S217 L219 S221 H222 A253 L268 K270 S271 T273 R276 E279 N280 G21 T22 Y23 D49 Y54 H116 Q189 Y215 S216 L218 S220 H221 A252 L267 K269 S270 T272 R275 E278 N279
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0032052 bile acid binding
GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO:0047023 androsterone dehydrogenase activity
GO:0047086 ketosteroid monooxygenase activity
GO:0050221 prostaglandin E2 9-reductase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006693 prostaglandin metabolic process
GO:0042448 progesterone metabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q5m, PDBe:1q5m, PDBj:1q5m
PDBsum1q5m
PubMed15123423
UniProtP80508|PE2R_RABIT Prostaglandin-E(2) 9-reductase (Gene Name=AKR1C5)

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