Structure of PDB 1pzm Chain B

Receptor sequence
>1pzmB (length=170) Species: 5689 (Leishmania tarentolae) [Search protein sequence]
YPMSARTLVTQEQVWAATAKCAKKIAADYKDFHLTADNPLYLLCVLKGSF
IFTADLARFLADEGVPVKVEFICAVRMLLDVRDSVENRHIMLVEDIVDSA
ITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPRAFVIG
YGMDFAESYRELRDICVLKK
3D structure
PDB1pzm Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E125 D126 D129 F178 R191
Catalytic site (residue number reindexed from 1) E94 D95 D98 F147 R160
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP B D126 I127 D129 S130 A131 T133 K157 F178 V179 D185 D95 I96 D98 S99 A100 T102 K126 F147 V148 D154
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:1pzm, PDBe:1pzm, PDBj:1pzm
PDBsum1pzm
PubMed17894860
UniProtQ9NJI5

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