Structure of PDB 1pyo Chain B

Receptor sequence
>1pyoB (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
PKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHV
ADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPP
3D structure
PDB1pyo Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.55: caspase-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B A229 M230 R231 N232 T233 W238 G272 Y273 F279 A23 M24 R25 N26 T27 W32 G66 Y67 F73
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1pyo, PDBe:1pyo, PDBj:1pyo
PDBsum1pyo
PubMed12920126
UniProtP42575|CASP2_HUMAN Caspase-2 (Gene Name=CASP2)

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