Structure of PDB 1pwu Chain B

Receptor sequence
>1pwuB (length=736) Species: 1392 (Bacillus anthracis) [Search protein sequence]
EEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIY
IVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQ
SSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTIKNASD
SDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQHRDV
LQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLSRYEKWEKIKQHYQHWS
DSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLST
EEKEFLKKLQIDIRDSLSEEEKELLNPLSEKEKEFLKKLKLDIQPYDINQ
RLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYEN
MNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINE
RPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEK
EYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNR
YASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIA
EQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHCFGH
AVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEA
FRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
3D structure
PDB1pwu The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 C687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H646 C647 H650 Y688 E695
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H686 H690 E735 H646 H650 E695
BS02 GM6 B H654 S655 K656 G657 G674 V675 H686 H690 Y728 H614 S615 K616 G617 G634 V635 H646 H650 Y688
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0030430 host cell cytoplasm
GO:0044164 host cell cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pwu, PDBe:1pwu, PDBj:1pwu
PDBsum1pwu
PubMed14718924
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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