Structure of PDB 1pvs Chain B

Receptor sequence
>1pvsB (length=282) Species: 562 (Escherichia coli) [Search protein sequence]
MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTA
IPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGA
ARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFP
EYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPG
DVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTP
AQIRRYAERWKPWRSYALLHIWYTEGWQPDEA
3D structure
PDB1pvs 3-methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W218 Y222 D238
Catalytic site (residue number reindexed from 1) W218 Y222 D238
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HP B G123 Q124 L125 W218 D237 D238 Y239 G123 Q124 L125 W218 D237 D238 Y239
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
GO:0005515 protein binding
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0016787 hydrolase activity
GO:0032131 alkylated DNA binding
GO:0043916 DNA-7-methylguanine glycosylase activity
GO:0052821 DNA-7-methyladenine glycosylase activity
GO:0052822 DNA-3-methylguanine glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006307 DNA alkylation repair
GO:0006950 response to stress
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex

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Cellular Component
External links
PDB RCSB:1pvs, PDBe:1pvs, PDBj:1pvs
PDBsum1pvs
PubMed12009927
UniProtP04395|3MG2_ECOLI DNA-3-methyladenine glycosylase 2 (Gene Name=alkA)

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