Structure of PDB 1pvr Chain B

Receptor sequence

>1pvrB (length=320) Species: 10678 (Punavirus P1) [Search protein sequence]

TSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEP
EDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMR
RIRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAY
NTLLRLAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVT
KLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSNSALGGIFGAT
HRLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNV
NIVMNYIRNLTGAMVRLLED

3D structure

PDB

1pvr A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and water.

Chain

Resolution

2.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K43 M44 S47 R50 R81 L83 A84 K86 T87 Q90 A131 K132 Q156 R159 R173 K201 T202 R241 V242 K244 L256 S257 S259 R282 R292 W315 T316 N317 I320 Y324	K25 M26 S29 R32 R63 L65 A66 K68 T69 Q72 A113 K114 Q138 R141 R155 K183 T184 R223 V224 K226 L238 S239 S241 R264 R274 W297 T298 N299 I302 Y306
BS02	dna	B	F37 S38 H40 T41 K43 Q90 R100 R106 R121 R173 L174 K201 R243 N245 S259 K276 R282 Y283 S287 G288 H289	F19 S20 H22 T23 K25 Q72 R82 R88 R103 R155 L156 K183 R225 N227 S241 K258 R264 Y265 S269 G270 H271

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1pvr, PDBe:1pvr, PDBj:1pvr
PDBsum	1pvr
PubMed	14652076
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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