Structure of PDB 1pvj Chain B

Receptor sequence
>1pvjB (length=339) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSG
DKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVV
KSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQ
IMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTY
SGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYN
QSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADG
RNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
3D structure
PDB1pvj Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C192 H340 W357
Catalytic site (residue number reindexed from 1) C143 H291 W308
Enzyme Commision number 3.4.22.10: streptopain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZFB B E115 N116 Q162 C192 S279 S280 G281 V337 H340 W359 E72 N73 Q113 C143 S230 S231 G232 V288 H291 W310
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0034050 symbiont-induced defense-related programmed cell death
GO:0042783 evasion of host immune response
GO:0140321 symbiont-mediated suppression of host autophagy
Cellular Component
GO:0005576 extracellular region
GO:0030430 host cell cytoplasm
GO:0043655 host extracellular space
GO:0044164 host cell cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pvj, PDBe:1pvj, PDBj:1pvj
PDBsum1pvj
PubMed
UniProtP0C0J0|SPEB_STRPY Streptopain (Gene Name=speB)

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