Structure of PDB 1pt9 Chain B

Receptor sequence
>1pt9B (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
PMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKML
TEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTD
LVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAA
VDNPIFYKPNTAMLLGDAKKTCDALQAKVRES
3D structure
PDB1pt9 Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation
ChainB
Resolution2.42 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y54 R89 D131 Y170
Catalytic site (residue number reindexed from 1) Y32 R67 D109 Y148
Enzyme Commision number 7.1.1.1: proton-translocating NAD(P)(+) transhydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TAP B G53 G55 V86 G88 R89 M90 P91 G128 A129 N130 D131 T132 K163 R164 S165 V168 G169 Y170 D189 A190 G31 G33 V64 G66 R67 M68 P69 G106 A107 N108 D109 T110 K141 R142 S143 V146 G147 Y148 D167 A168
External links
PDB RCSB:1pt9, PDBe:1pt9, PDBj:1pt9
PDBsum1pt9
PubMed12791694
UniProtQ13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial (Gene Name=NNT)

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