Structure of PDB 1p8x Chain B

Receptor sequence
>1p8xB (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
DDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHQGQIIYNW
QGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKP
MIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDA
FVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWE
ALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDL
ATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTP
ITVVKQGFEPPSFVGWFLGWDDDYW
3D structure
PDB1p8x Activation in isolation: Exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B G444 D445 E475 T524 G31 D32 E59 T108
BS02 CA B N564 D565 E587 N148 D149 E171
BS03 CA B D669 D670 E692 D253 D254 E276
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:1p8x, PDBe:1p8x, PDBj:1p8x
PDBsum1p8x
PubMed14527664
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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