Structure of PDB 1p7d Chain B

Receptor sequence

>1p7dB (length=280) Species: 10710 (Lambdavirus lambda)

MTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLTTKEIAA
MLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVR
RSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVD
GYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTR
REPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKF
AQHLLGHKSDTMASQYRDDRGREWDKIEIK

3D structure

• PDB: 1p7d A Conformational Switch Controls the DNA Cleavage Activity of Lambda Integrase
• Chain: B
• Resolution: 2.95 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K105 K136 A138 S139 V175 R176 R177 Y288 H308 Y342 R346	K32 K60 A62 S63 V99 R100 R101 Y212 H232 Y266 R270
BS02	dna	B	R90 I92 K93 K95 T96 N99 Y100 G214 S234 K235 R276 G283 S286 R287 M290 T306 H308 H333 K334 S335 S340 Q341 Y342	R17 I19 K20 K22 T23 N26 Y27 G138 S158 K159 R200 G207 S210 R211 M214 T230 H232 H257 K258 S259 S264 Q265 Y266

Gene Ontology

Molecular Function

• GO:0003677 DNA binding

Biological Process

• GO:0006310 DNA recombination
• GO:0015074 DNA integration

External links

• PDB: RCSB:1p7d, PDBe:1p7d, PDBj:1p7d
• PDBsum: 1p7d
• PubMed: 12887904
• UniProt: P03700|VINT_LAMBD Integrase (Gene Name=int)