Structure of PDB 1p6i Chain B

Receptor sequence
>1p6iB (length=410) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPVRTKDQLFPL
AKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKH
AWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRS
AITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ
QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDL
GLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNIL
EEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATES
FIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ
PDPWNTHVWK
3D structure
PDB1p6i Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C415 R418 W587 E592
Catalytic site (residue number reindexed from 1) C108 R111 W280 E285
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C326 C331 C28 C33
BS02 H4B B F691 H692 E694 F384 H385 E387
BS03 HEM B W409 C415 G417 M570 F584 S585 W587 E592 W678 F704 Y706 W102 C108 G110 M263 F277 S278 W280 E285 W371 F397 Y399
BS04 H4B B S334 R596 V677 W678 S36 R289 V370 W371
BS05 DP3 B P565 S585 G586 W587 E592 P258 S278 G279 W280 E285 MOAD: Ki=0.15uM
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1p6i, PDBe:1p6i, PDBj:1p6i
PDBsum1p6i
PubMed14718923
UniProtP29476|NOS1_RAT Nitric oxide synthase 1 (Gene Name=Nos1)

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