Structure of PDB 1p61 Chain B

Receptor sequence
>1p61B (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTNGGNV
LQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVY
SDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQAT
PETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEV
PILTLDVNEDFKDKYESLVEKVKEFLSTL
3D structure
PDB1p61 Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.113: deoxyguanosine kinase.
2.7.1.74: deoxycytidine kinase.
2.7.1.76: deoxyadenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B A31 G33 K34 S35 T36 R188 D241 F242 A12 G14 K15 S16 T17 R157 D210 F211
BS02 DCZ B I30 E53 V55 W58 Y86 F96 Q97 D133 F137 E197 I11 E34 V36 W39 Y55 F65 Q66 D102 F106 E166
Gene Ontology
Molecular Function
GO:0004136 deoxyadenosine kinase activity
GO:0004137 deoxycytidine kinase activity
GO:0004138 deoxyguanosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019136 deoxynucleoside kinase activity
GO:0042803 protein homodimerization activity
GO:0043771 cytidine kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0106383 dAMP salvage
GO:1901135 carbohydrate derivative metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1p61, PDBe:1p61, PDBj:1p61
PDBsum1p61
PubMed12808445
UniProtP27707|DCK_HUMAN Deoxycytidine kinase (Gene Name=DCK)

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