Structure of PDB 1p57 Chain B

Receptor sequence
>1p57B (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVL
SRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFNSNDIALVHLSSPLPL
TEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISN
DVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRW
RLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ
3D structure
PDB1p57 The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D88 Q181 G182 D183 S184 G185
Enzyme Commision number 3.4.21.106: hepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CR4 B H57 D189 A190 C191 Q192 S195 V213 H41 D178 A179 C180 Q181 S184 V206 MOAD: Ki=40uM
PDBbind-CN: -logKd/Ki=4.40,Ki=40uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1p57, PDBe:1p57, PDBj:1p57
PDBsum1p57
PubMed12962630
UniProtP05981|HEPS_HUMAN Serine protease hepsin (Gene Name=HPN)

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