Structure of PDB 1p31 Chain B

Receptor sequence
>1p31B (length=465) Species: 727 (Haemophilus influenzae) [Search protein sequence]
RKIIPEMRRVQQIHFIGIGGAGMSGIAEILLNEGYQISGSDIADGVVTQR
LAQAGAKIYIGHAEEHIEGASVVVVSSAIKDDNPELVTSKQKRIPVIQRA
QMLAEIMRFRHGIAVAGTHGKTTTTAMISMIYTQAKLDPTFVNGGLVKSA
GKNAHLGASRYLIAEADESDASFLHLQPMVSVVTNMEPDHMDTYEGDFEK
MKATYVKFLHNLPFYGLAVMCADDPVLMELVPKVGRQVITYGFSEQADYR
IEDYEQTGFQGHYTVICPNNERINVLLNVPGKHNALNATAALAVAKEEGI
ANEAILEALADFQGAGRRFDQLGEFIRPNGKVRLVDDYGHHPTEVGVTIK
AAREGWGDKRIVMIFQPHRYSRTRDLFDDFVQVLSQVDALIMLDVYAAGE
APIVGADSKSLCRSIRNLGKVDPILVSDTSQLGDVLDQIIQDGDLILAQG
AGSVSKISRGLAESW
3D structure
PDB1p31 Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K129 T130 L154 E173 H198
Catalytic site (residue number reindexed from 1) K121 T122 L146 E165 H190
Enzyme Commision number 6.3.2.8: UDP-N-acetylmuramate--L-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EPU B G25 G27 G28 A29 G30 M31 D49 I50 H70 S84 A86 I87 R107 D175 S177 H198 G17 G19 G20 A21 G22 M23 D41 I42 H62 S76 A78 I79 R99 D167 S169 H190
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1p31, PDBe:1p31, PDBj:1p31
PDBsum1p31
PubMed12837790
UniProtP45066|MURC_HAEIN UDP-N-acetylmuramate--L-alanine ligase (Gene Name=murC)

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