Structure of PDB 1p0c Chain B

Receptor sequence
>1p0cB (length=372) Species: 8403 (Pelophylax perezi) [Search protein sequence]
CTAGKDITCKAAVAWEPHKPLSLETITVAPPKAHEVRIKILASGICGSDS
SVLKEIIPSKFPVILGHEAVGVVESIGAGVTCVKPGDKVIPLFVPQCGSC
RACKSSNSNFCEKNDMGAKTGLMADMTSRFTCRGKPIYNLMGTSTFTEYT
VVADIAVAKIDPKAPLESCLIGCGFATGYGAAVNTAKVTPGSTCAVFGLG
GVGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGATECLNPKDYDKPIY
EVICEKTNGGVDYAVECAGRIETMMNALQSTYCGSGVTVVLGLASPNERL
PLDPLLLLTGRSLKGSVFGGFKGEEVSRLVDDYMKKKINVNFLVSTKLTL
DQINKAFELLSSGQGVRSIMIY
3D structure
PDB1p0c Crystal Structure of the Vertebrate NADP(H)-dependent Alcohol Dehydrogenase (ADH8)
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C2046 G2047 S2048 S2051 H2067 E2068 C2097 C2100 C2103 C2111 D2115 C2173 T2177 R2367
Catalytic site (residue number reindexed from 1) C46 G47 S48 S51 H67 E68 C97 C100 C103 C111 D115 C173 T177 R367
Enzyme Commision number 1.1.1.2: alcohol dehydrogenase (NADP(+)).
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN B C2097 C2100 C2103 C2111 C97 C100 C103 C111
BS02 ZN B C2046 S2048 H2067 C46 S48 H67
BS03 PO4 B G2047 G2201 V2202 R2367 G47 G201 V202 R367
Gene Ontology
Molecular Function
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Biological Process

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Cellular Component
External links
PDB RCSB:1p0c, PDBe:1p0c, PDBj:1p0c
PDBsum1p0c
PubMed12818203
UniProtO57380|ADH8_PELPE NADP-dependent alcohol dehydrogenase (Gene Name=ADH8)

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