Structure of PDB 1osv Chain B

Receptor sequence
>1osvB (length=229) Species: 10116 (Rattus norvegicus) [Search protein sequence]
AELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEENFLILTEMAT
SHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPA
GHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILS
PDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRT
FNHHHAEMLMSWRVNDHKFTPLLCEIWDV
3D structure
PDB1osv Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V296 K300 H310 K318 L461 E464 V57 K61 H71 K79 L222 E225
BS02 peptide B Q264 E286 Q293 Q25 E47 Q54
BS03 CHC B M262 M287 A288 H291 M325 F326 R328 S329 F333 I349 Y358 Y366 H444 M23 M48 A49 H52 M86 F87 R89 S90 F94 I110 Y119 Y127 H205
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1osv, PDBe:1osv, PDBj:1osv
PDBsum1osv
PubMed12718893
UniProtQ62735|NR1H4_RAT Bile acid receptor (Gene Name=Nr1h4)

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