Structure of PDB 1on8 Chain B

Receptor sequence
>1on8B (length=262) Species: 10090 (Mus musculus) [Search protein sequence]
ALDSFTLIMQTYNRTDLLLRLLNHYQAVPSLHKVIVVWNNVGEKGPEELW
NSLGPHPIPVIFKPQTANKMRNRLQVFPEVETNAVLMVDDDTLISAQDLV
FAFSIWQQFPDQIIGFVPRKHVSTSSGIYSYGGFELQTPGPGNGDQYSMV
LIGASFFNSKYLELFQKQPAAVHALIDETQNCDDIAMNFLVTRHTGKPSG
IFVKPINMVNLEKETSGMWHRAEHFLQRSYCINKLVNIYDGMPLKYSNIM
ISQFGFPYANHK
3D structure
PDB1on8 Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BDP B R181 Y193 R293 R119 Y131 R228
BS02 UDP B Q72 T73 Y74 R76 N130 D151 D152 M283 W284 Q10 T11 Y12 R14 N68 D89 D90 M218 W219
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1on8, PDBe:1on8, PDBj:1on8
PDBsum1on8
PubMed12562774
UniProtQ9ES89|EXTL2_MOUSE Exostosin-like 2 (Gene Name=Extl2)

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