Structure of PDB 1omz Chain B

Receptor sequence
>1omzB (length=255) Species: 10090 (Mus musculus) [Search protein sequence]
SALDSFTLIMQTYNRTDLLLRLLNHYQAVPSLHKVIVVWNNVGEKGPEEL
WNSLGPHPIPVIFKPQTANKMRNRLQVFPEVETNAVLMVDDDTLISAQDL
VFAFSIWQQFPDQIIGFVPRKHVSTSSGIYSYGGFELQTPGPGNGDQYSM
VLIGASFFNSKYLELFQKQPAAVHALIDETQNCDDIAMNFLVTRHTGKPS
GIFVKPINMVNLERAEHFLQRSYCINKLVNIYDGMPLKYSNIMISQFGFP
YANHK
3D structure
PDB1omz Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UD2 B Q72 T73 Y74 R76 N101 N130 M132 R135 D151 D152 L213 D246 H289 R293 Q11 T12 Y13 R15 N40 N69 M71 R74 D90 D91 L152 D185 H217 R221
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:1omz, PDBe:1omz, PDBj:1omz
PDBsum1omz
PubMed12562774
UniProtQ9ES89|EXTL2_MOUSE Exostosin-like 2 (Gene Name=Extl2)

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