Structure of PDB 1oao Chain B

Receptor sequence

>1oaoB (length=673) Species: 1525 (Moorella thermoacetica) [Search protein sequence]

PRFRDLSHNCRPSEAPRVMEPKNRDRTVDPAVLEMLVKSKDDKVITAFDR
FVAQQPQCKIGYEGICCRFCMAGPCRIKATDGPGSRGICGASAWTIVARN
VGLMILTGAAAHCEHGNHIAHALVEMAEGKAPDYSVKDEAKLKEVCRRVG
IEVEGKSVLELAQEVGEKALEDFRRLKGEGEATWLMTTINEGRKEKFRTH
NVVPFGIHASISELVNQAHMGMDNDPVNLVFSAIRVALADYTGEHIATDF
SDILFGTPQPVVSEANMGVLDPDQVNFVLHGHNPLLSEIIVQAAREMEGE
AKAAGAKGINLVGICCTGNEVLMRQGIPLVTSFASQELAICTGAIDAMCV
DVQCIMPSISAVAECYHTRIITTADNAKIPGAYHIDYQTATAIESAKTAI
RMAIEAFKERKESNRPVYIPQIKNRVVAGWSLEALTKLLATQNAQNPIRV
LNQAILDGELAGVALICGCNNLKGFQDNSHLTVMKELLKNNVFVVATGCS
AQAAGKLGLLDPANVETYCGDGLKGFLKRLGEGANIEIGLPPVFHMGSCV
DNSRAVDLLMAMANDLGVDTPKVPFVASAPEAMSGKAAAIGTWWVSLGVP
THVGTMPPVEGSDLIYSILTQIASDVYGGYFIFEMDPQVAARKILDALEY
RTWKLGVHKEVAERYETKLCQGY

3D structure

PDB

1oao Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] Clusters in Closed and Open Alpha Subunits of Acetyl-Coa Synthase/Carbon Monoxide Dehydrogenase

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.2.7.4: anaerobic carbon-monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SF4	B	C59 G62 C67 R69	C58 G61 C66 R68
BS02	SF4	B	C68 F70 C71 G74 C76 I89 C90 R100 M221	C67 F69 C70 G73 C75 I88 C89 R99 M220
BS03	XCC	B	H283 C316 C317 F334 C355 G469 C470 C500 C550 S585 K587	H282 C315 C316 F333 C354 G468 C469 C499 C549 S584 K586
BS04	BCT	B	R148 V154 E155	R147 V153 E154
BS05	FE2	B	H283 C317 C550	H282 C316 C549

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004601	peroxidase activity
GO:0016151	nickel cation binding
GO:0016491	oxidoreductase activity
GO:0043885	anaerobic carbon-monoxide dehydrogenase activity
GO:0046872	metal ion binding
GO:0050418	hydroxylamine reductase activity
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006091	generation of precursor metabolites and energy
GO:0015977	carbon fixation
GO:0042542	response to hydrogen peroxide
GO:0098869	cellular oxidant detoxification

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Molecular Function

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Biological Process

External links

PDB	RCSB:1oao, PDBe:1oao, PDBj:1oao
PDBsum	1oao
PubMed	12627225
UniProt	P27989\|DCMB_MOOTH Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit beta

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