Structure of PDB 1o3p Chain B

Receptor sequence
>1o3pB (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKEASTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
3D structure
PDB1o3p Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
ChainB
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H46 D97 Q195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N26 W29 P49 P114 Q119 T120 I121 C122 M207 N11 W14 P38 P113 Q118 T119 I120 C121 M210
BS02 655 B H57 C58 S190 C191 Q192 S195 V213 W215 H46 C47 S193 C194 Q195 S198 V216 W218 MOAD: Ki=0.22uM
PDBbind-CN: -logKd/Ki=6.66,Ki=0.22uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1o3p, PDBe:1o3p, PDBj:1o3p
PDBsum1o3p
PubMed12742021
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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