Structure of PDB 1nzb Chain B

Receptor sequence

>1nzbB (length=322) Species: 10678 (Punavirus P1) [Search protein sequence]

SDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPE
DVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRR
IRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYN
TLLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTK
LVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATH
RLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVN
IVMNYIRNLDSETGAMVRLLED

3D structure

PDB

1nzb Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K43 M44 R81 L83 A84 K86 T87 Q90 A131 K132 R159 R173 K201 T202 R241 V242 K244 L256 S257 R259 R282 R292 W315 T316 N317 Y324	K24 M25 R62 L64 A65 K67 T68 Q71 A112 K113 R140 R154 K182 T183 R222 V223 K225 L237 S238 R240 R263 R273 W296 T297 N298 Y305
BS02	dna	B	F37 S38 H40 T41 M97 R100 R101 R106 R121 I174 A175 K244 N245 R259 E262 R282 Y283 S287 G288 H289	F18 S19 H21 T22 M78 R81 R82 R87 R102 I155 A156 K225 N226 R240 E243 R263 Y264 S268 G269 H270

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1nzb, PDBe:1nzb, PDBj:1nzb
PDBsum	1nzb
PubMed	12954782
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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