Structure of PDB 1nvt Chain B

Receptor sequence
>1nvtB (length=287) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
GPLGSMINAKTKVIGLIGHPVEHSFSPIMHNAAFKDKGLNYVYVAFDVLP
ENLKYVIDGAKALGIVGFNVTIPHKIEIMKYLDEIDKDAQLIGAVNTIKI
EDGKAIGYNTDGIGARMALEEEIGRVKDKNIVIYGAGGAARAVAFELAKD
NNIIIANRTVEKAEALAKEIAEKLNKKFGEEVKFSGLDVDLDGVDIIINA
TPIGMYPNIDVEPIVKAEKLREDMVVMDLIYNPLETVLLKEAKKVNAKTI
NGLGMLIYQGAVAFKIWTGVEPNIEVMKNAIIDKITK
3D structure
PDB1nvt Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution
ChainB
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K75 D111
Catalytic site (residue number reindexed from 1) K75 D111
Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E22 H23 E22 H23
BS02 NAP B I72 G135 G137 G138 A139 N157 R158 T159 K162 A200 T201 P202 I203 M205 L229 Y231 M255 L256 I72 G135 G137 G138 A139 N157 R158 T159 K162 A200 T201 P202 I203 M205 L229 Y231 M255 L256
Gene Ontology
Molecular Function
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019632 shikimate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1nvt, PDBe:1nvt, PDBj:1nvt
PDBsum1nvt
PubMed12906831
UniProtQ58484|AROE_METJA Shikimate dehydrogenase (NADP(+)) (Gene Name=aroE)

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