Structure of PDB 1nvf Chain B

Receptor sequence
>1nvfB (length=388) Species: 162425 (Aspergillus nidulans) [Search protein sequence]
PTKISILGRESIIADFGLWRNYVAKDLISDCSSTTYVLVTDTNIGSIYTP
SFEEAFRKRAAEITPSPRLLIYNRPPGEVSKSRQTKADIEDWMLSQNPPC
GRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQVPTTLLAMVDSSIGGKT
AIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIKTAAISS
EEEFTALEENAETILKAVRREVTPGEHRFEGTEEILKARILASARHKAYV
VSADEREGGLRNLLNWGHSIGHAIEAILTPQILHGECVAIGMVKEAELAR
HLGILKGVAVSRIVKCLAAYGLPTSLKDARIRKLTAGKHCSVDQLMFNMA
LDKKNDGPKKKIVLLSAIGTPYETRASVVANEDIRVVL
3D structure
PDB1nvf Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R130 K152 E194 K250 E260 R264 N268 H271 H275 H287
Catalytic site (residue number reindexed from 1) R127 K149 E191 K247 E257 R261 N265 H268 H272 H284
Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).
2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.
2.7.1.71: shikimate kinase.
4.2.1.10: 3-dehydroquinate dehydratase.
4.2.3.4: 3-dehydroquinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E194 H271 H287 E191 H268 H284
BS02 ADP B D44 I47 P79 G114 G115 V116 T139 T140 T182 L183 E187 D41 I44 P76 G111 G112 V113 T136 T137 T179 L180 E184
BS03 CRB B D146 K152 N162 E194 K250 R264 L267 N268 H271 H275 H287 K356 D143 K149 N159 E191 K247 R261 L264 N265 H268 H272 H284 K353
Gene Ontology
Molecular Function
GO:0003856 3-dehydroquinate synthase activity
GO:0016838 carbon-oxygen lyase activity, acting on phosphates
Biological Process
GO:0009073 aromatic amino acid family biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nvf, PDBe:1nvf, PDBj:1nvf
PDBsum1nvf
PubMed12614613
UniProtP07547|ARO1_EMENI Pentafunctional AROM polypeptide (Gene Name=aromA)

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