Structure of PDB 1nug Chain B

Receptor sequence
>1nugB (length=679) Species: 9606 (Homo sapiens) [Search protein sequence]
AALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSN
ERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISIS
SPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAE
REEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRR
DAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWD
GSVEILKNWKKSGLSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAH
DTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQ
VLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWL
YDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQ
VFQKALGKLLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKT
VTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYERYL
KSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQ
MLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKERSRVRFDILPS
RSGTKQLLADFSCNKFPAIKAMLSIDVAE
3D structure
PDB1nug Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W236 C272 H330 D353 Y525
Catalytic site (residue number reindexed from 1) W236 C272 H330 D353 Y512
Enzyme Commision number 2.3.2.13: protein-glutamine gamma-glutamyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B A221 N224 S225 N226 D228 A221 N224 S225 N226 D228
BS02 CA B N393 S415 E443 E448 N393 S415 E443 E448
BS03 MG B D301 D303 N305 S307 D301 D303 N305 S307
Gene Ontology
Molecular Function
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0003824 catalytic activity
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031069 hair follicle morphogenesis
GO:0031424 keratinization
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nug, PDBe:1nug, PDBj:1nug
PDBsum1nug
PubMed12679341
UniProtQ08188|TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E (Gene Name=TGM3)

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