Structure of PDB 1nrl Chain B

Receptor sequence
>1nrlB (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVREEAAKWSQVRKDL
CSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIIS
FAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY
CLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGV
LQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQ
HTQRLLRIQDIHPFATPLMQELFGI
3D structure
PDB1nrl Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I255 K259 I269 E270 Q272 K277 P423 L424 E427 I99 K103 I113 E114 Q116 K121 P267 L268 E271
BS02 SRL B L209 M243 S247 Q285 W299 Y306 M323 H327 H407 L411 F420 F429 L53 M87 S91 Q129 W143 Y150 M167 H171 H251 L255 F264 F273 BindingDB: EC50=440nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrl, PDBe:1nrl, PDBj:1nrl
PDBsum1nrl
PubMed12909012
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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