Structure of PDB 1nop Chain B

Receptor sequence
>1nopB (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDV
DWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIA
FGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADG
THKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGST
PGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADE
SKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA
EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANL
SKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPY
DLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP
3D structure
PDB1nop Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y204 H263 P461 S518 Y46 H105 P294 S351
BS02 VO4 B H263 K265 H493 K495 H105 K107 H326 K328 BindingDB: IC50=4000nM
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nop, PDBe:1nop, PDBj:1nop
PDBsum1nop
PubMed12618186
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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