Structure of PDB 1nnl Chain B

Receptor sequence
>1nnlB (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
SELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEPFKAALTE
RLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRS
IVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKL
LKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYIT
DFVELLG
3D structure
PDB1nnl High-resolution structure of human phosphoserine phosphatase in open conformation.
ChainB
Resolution1.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D20 V21 D22 G110 K158 D183
Catalytic site (residue number reindexed from 1) D16 V17 D18 G96 K144 D169
Enzyme Commision number 3.1.3.3: phosphoserine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D20 D22 D179 D16 D18 D165
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0036424 L-phosphoserine phosphatase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0009612 response to mechanical stimulus
GO:0031667 response to nutrient levels
GO:0033574 response to testosterone
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1nnl, PDBe:1nnl, PDBj:1nnl
PDBsum1nnl
PubMed12777757
UniProtP78330|SERB_HUMAN Phosphoserine phosphatase (Gene Name=PSPH)

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