Structure of PDB 1ng9 Chain B

Receptor sequence
>1ng9B (length=766) Species: 562 (Escherichia coli) [Search protein sequence]
AHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTPI
PMAGIPYHAVENYLAKLVNQGESVAICEQVERKVVRIVTPGTISDEALLQ
ERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPA
ELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFG
VENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRN
LEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQ
TIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLP
ELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIA
SGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQ
ISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQ
LYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKP
GIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQ
TALIALMAYIGSYVPAQKVEIGPIDRIFTRVGASTFMVEMTETANILHNA
TEYSLVLMDEIGAGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQ
LPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKE
VIKRARQKLRELESIS
3D structure
PDB1ng9 The alternating ATPase domains of MutS control DNA mismatch repair
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Q95 L495 K496 R500 Q79 L469 K470 R474 PDBbind-CN: Kd=9.6uM
BS02 ADP B F596 I597 M617 G618 G619 K620 S621 T622 H760 F570 I571 M591 G592 G593 K594 S595 T596 H726
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ng9, PDBe:1ng9, PDBj:1ng9
PDBsum1ng9
PubMed12554674
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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