Structure of PDB 1nbi Chain B

Receptor sequence
>1nbiB (length=275) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGT
GVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRKEPAFDKWVIEEANW
LTLDKDVPAGDGFDAVICLGNSFAHLPDSKGDQSEHRLALKNIASMVRPG
GLLVIDHKNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVT
LDYTVQVPGAGRDGAPGFSKFRLSYYPHCLASFTELVQEAFGGRCQHSVL
GDFKPYRPGQAYVPCYFIHVLKKTG
3D structure
PDB1nbi Catalytic mechanism of glycine N-methyltransferase
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y21 G137 H142 K175 Y194
Catalytic site (residue number reindexed from 1) Y4 G120 H125 K158 Y177
Enzyme Commision number 2.1.1.20: glycine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B Y21 W30 R40 V69 D85 A86 S87 M90 N116 W117 S139 Y194 Y4 W13 R23 V52 D68 A69 S70 M73 N99 W100 S122 Y177
Gene Ontology
Molecular Function
GO:0005542 folic acid binding
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016594 glycine binding
GO:0017174 glycine N-methyltransferase activity
GO:0042802 identical protein binding
GO:0098603 selenol Se-methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006544 glycine metabolic process
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0032259 methylation
GO:0046498 S-adenosylhomocysteine metabolic process
GO:0046500 S-adenosylmethionine metabolic process
GO:0051289 protein homotetramerization
GO:1901052 sarcosine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034708 methyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nbi, PDBe:1nbi, PDBj:1nbi
PDBsum1nbi
PubMed12859184
UniProtP13255|GNMT_RAT Glycine N-methyltransferase (Gene Name=Gnmt)

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